Once again, Dr. Claire O’Shaunessy is doing battle for one of her patients. Only this time, it’s Elizabeth, Chicago Mayor Keeley’s sister. Mayor Keeley is part of a large family, so he expects things to happen, such as bike accidents, missing pets, etc. When the mayor’s sister dies after routine surgery, Detective Patrick O’Shaunessy, Claire’s brother, starts noticing the accident, and now body count is rising. And to add to Patrick’s workload, he and his partner, Detective Jack Miller are assigned a high profile case of a missing local television reporter.